Treatment Options

  • The initial management of restless legs should include patient education (see resources section), investigation and correction (where feasible) of secondary causes, withdrawal of associated medication if possible and safe.
  • Consider the use of the validated patient symptom self-rating scale from the IRLSSG

Doctor holding lower leg of patient

  • Give self help advice
    • Good sleep hygiene
    • Stop smoking support
    • Moderate exercise
    • Reduce excessive caffeine, alcohol or chocolate consumption
  • Discuss ways of alleviating symptoms
    • Relaxation exercises
    • Heat (pad or warm bath)
    • Massaging affected limbs
    • Distraction at times of rest (reading, mental games)
    • Walking or stretching
  • For people with idiopathic restless legs syndrome consider the impact of their symptoms
    • Mild symptoms may be managed by the education and self help measures discussed above
    • Moderate to severe symptoms may require drug treatment

You may find this algorithm useful

Drug treatments for restless legs

When deciding on a drug treatment for symptom control, a number of factors must be taken into account. The medications used in this condition have potential severe side effects and none are suitable for restless legs in pregnancy.

Prior to commencing drug treatment patients should be aware of the ill effects (see below), the fact that they will potentially need to take the medication life-long and that the efficacy may wane with time.

Treatment option To be noted

Dopamine agonists

Pramipexole or Ropinirole or Rotigotine

  • 1st line choice (or gabapentin/Pregabalin)
  • Risk of symptom augmentation
  • Risk of sudden daytime sleep onset
  • Risk of impulse control disorder (see below)
  • Preferred for patients with co-morbid depression, obesity, at risk of falls or with cognitive impairment
Pregabalin or Gabapentin
  • 1st line choice (or dopamine agonist)
  • Off-licence
  • Preferred for patients with history of impulse control disorder, co-morbid anxiety, chronic pain or severe sleep disturbance
Weak Opioids e.g. Codeine
  • May be an alternative for pain control
Hypnotics Benzodiazepines or Z-drugs
  • Intermittent use of hypnotics may be necessary for severe sleep disturbance
  • Dependence (and loss of effectiveness) is a major limiting factor

Impulse control disorder

Impulse control disorder is an important and frequent side effect of dopamine agonists. Up to 17% of patients with restless legs syndrome taking these drugs may be affected. Symptoms include pathological gambling, binge eating, compulsive shopping, and hypersexuality. Prior to initiation the patient should be counselled and partners, carers or close family members should be aware of the signs. If present, the dopamine agonist should be withdrawn or the dosage reduced to a level at which the impulse control disorder disappears.



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